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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43f273f1f456557588e0903adac9e365a22e3e7b684f87d62091280237655923' 
  AND token = '2kHh5smUltvWU+DaiWF5RAyWiGnToBc3E6LACEq/kWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}