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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c8bb8a9d943878f47734749ddb845e39d1a84a8b9aaef1583682459b66e127b' 
  AND token = 'UF4pCnguJMACVslrUIj9TXt/2rjE2uHSe7Ll/JqmCn0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}