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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b49e22c2d74a826b901270b01a51ee7ea2ae74d064cbfd483d368ba8e79c5de9' 
  AND token = 'KyHCVp7x5i2PvAbH7ZTT/E+kTn+R7jHxFA0ObdLRh4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}