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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52547ff38ec7ca67e448ce8cb3bdf4aa6c6bb7909e33af04171e8954e0387368' 
  AND token = 'XZ4ZX7uAlvY14vqagecOrF1mQbaIf/LCS5TSpJpaC9g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00059

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}