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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8461e4a0cd03e50823926f594f0788b106597821a9bbc04e51d0972aef56e298' 
  AND token = 'PzrvoLbdfOaiOqWzSiuZVxErPneNJNByXoHrSeOm4Fo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}