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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2acd641ec91a8fbd19043f10487af66cd6cc9f8722628d48b2664980e0f72f60' 
  AND token = '8ymDR4pLgVDFdcfSts2O5sq++/6e3wjRJtPRDKlE8Vc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}