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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43fdd67bef77e3712480b2763e31e00d3edd887e5a735308afa2b5af067f1613' 
  AND token = 'B/sXvO/j8Qai2A147NlJGyD14T4eYxRW4pLLsPhiPp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}